HORDB

ID: hor000850
Uniprot ID: Q5NRP8
Protein name: Endothelin-2
Gene name: EDN2
Organism: Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)
Family: Endothelin/sarafotoxin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Atelerix (genus), Erinaceinae (subfamily), Erinaceidae (family), Eulipotyphla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0019229 regulation of vasoconstriction; GO:0042310 vasoconstriction; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Sequence: CSCNSWLDKECVYFCHLDIIW
Length: 21
Propeptide: MVALPTAWCSVALALLVALHEGKSQSAATSEEPPAPSARARGSHLRLRRCSCNSWLDKECVYFCHLDIIWVNTPGQTAPYGLGNPPRRQRRSLPRRCECYSTRDSACVTFCHQKPWPKASAVPGEGSPTDLLWTSKTRTTAGELLRRLRDIFAAKRNFTRHQQQKATREPESSHSRWRKR
Signal peptide: MVALPTAWCSVALALLVALHEGKSQS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000850_AF2.pdb

hor000850_ESM.pdb

Mass:	293493	Formula:	C116H165N27O32S4
Absent amino acids:	AGMPQRT	Common amino acids:	C
pI:	4.37	Basic residues:	2
Polar residues:	8	Hydrophobic residues:	8
Hydrophobicity:	37.14	Boman Index:	-1156
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	88.1
Instability Index:	5571.9	Extinction Coefficient cystines:	12740
Absorbance 280nm:	637